In this thought-provoking keynote, Dr. Shonna Waters explores the unprecedented challenges and opportunities facing HR professionals in today's rapidly evolving workplace. She examines how fundamental principles of work organization are being questioned, using the movement towards skills-based organizations as a case study. Dr. Waters argues that these shifts reflect a deeper need for organizational agility and adaptability in the face of volatility and uncertainty. Drawing from cutting-edge research, she presents a compelling illustration of fundamentally re-examining our approach to work, highlighting the mutually reinforcing relationship between individual well-being and organizational performance. The keynote introduces the concept of psychological ergonomics as a guiding principle for leveraging AI to create more human-centric work environments. Dr. Waters concludes with practical strategies for Total Rewards professionals to drive meaningful change in their organizations, emphasizing the importance of seizing opportunities presented by environmental jolts.